Slimjohn

Post tags: | atherosclerosis | heart_health | slimjohn |

heartlifetalk.com/forums REGRESSION - How I did it! » Arteries Are Better Today Than 9 Years Ago!! - by slimjohn

heartlifetalk.com/forums ADVANCED TOPICS » YOUR Lab & Test Results: Feedback » Advice Needed on Latest Scan by LVL

I highly recommend that you take sufficient vitamin D3, vitamin A, and vitamin K complex with a lot of MK-7 to prevent calcification.

Good on the homocysteine decrease!

Try taking pure niacin (nicotinic acid); start at low dose and work up. I used to take Slo-Niacin and pure niacin flush is not any different. Take after a meal and drink plenty of fluid.

Also, consider taking aged garlic with the fish oil. There is a synergistic effect. See my post on this thread: “Fish Oil still good??” I take 2 capsules 2x daily of Kyolic Aged Garlic Extract Extra Strength RESERVE Cardiovascular (iherb.com carries this). Each capsule is 600mg. See this thread “Aged Garlic Reverses Soft Plaque by 80% in New Study.”

slimjohn on kyolic garlic

Thanks for the update! Well, that article – apparently his organization released it to PR news organization – should have been reviewed before release. Makes me wonder how anyone, particularly those in research, can accidentally confuse 1200mg with 2400mg. Not only that, but there has been no correction AFAIK. Dr. Budoff made a presentation at the 9th annual scientific meeting of the Society of Cardiovascular Computed Tomography to be held July 10-13, 2014 in San Diego, California. I’ve not see anything on the study in print.

Nevertheless, I will stay with the 2400 mg AGE and evaluate throughout the remainder of the year (some things take longer to show consistent benefits). The PR news mistake may be the best unintentional benefit. :-) As with most substances, the rate of benefit effects decline with dosage so 2x dosage does not necessarily mean 2x benefit outcomes. Anything above 1x is okay with me. LOL

Regardless, this is one substance where being aggressive may just be optimal at least beyond the plaque reduction. It reduces vascular smooth muscle proliferation, decreases oxLDL, increases eNOS and NO (endothelial function), and naturally increases the endogenous antioxidants glutathione, glutathione reductase, and SOD (superoxide dismutase), improves lipids via reduction of HMG COA reductase (similar to statins) to reduce total cholesterol and triglycerides. I especially like natural induced increase in endogenous antioxidants. It also increases activation of AMPK so all good to me.

Linda - LCL: I've had similar huge swings in LDL-P and I've got Lp(a) as well. Dr. D has mentioned several times that some folks, especially those with Lp(a) are very sensitive to carbohydrate indulgences, such that they can cause huge increases in small particles and take weeks to wear off. I'm kind of thinking that's what it might be.

The H Factor Solution: Homocysteine, the Best Single Indicator of Whether You Are Likely to Live Long or Die Young. authors: James Braly M.D., Patrick Holford, Jonathan Wright M.D.

slimjohn on homocysteine
Following the guidelines of The H Factor Solution should reduce homocysteine. However, for some, getting to 6 may not be so easy. While the authors offer suggestions on diet and supplements, keep in mind that one's mileage may differ and they may be insufficient. For example, folic acid may work for some people but for most 5-MTHR (methlyfolate) is superior. Some people may require higher dosages methylfolate than recommended (I do!). They mention TMG (TMG converts homocysteine back to methionine) but note that they state that for some people much higher dosages may be required. If you are sensitive to too much methyl groups/TMG you may experience side effects (fatigue, nausea, hair loss, dizziness, spaciness). So, it may be best at some time to consider optimizing methylation and to know how the various B vitamins effect certain polymorphisms. Since methylation is a big, critical part of reducing homocysteine, it may be best to get 23andme genetic data to see what specifically may need addressing to optimize methylation. Make the adjustments and follow up with methylation panel to confirm. For example, I have COMT polymorphism that processes methyl groups slowly. I take niacin that consumed methyl groups and seems to offset COMT effects. That's a double benefit. I've had to make adjustments after adding TMG which seems to work directly within the methionione cycle and does not effect COMT (I've not noticed). I added TMG about 3 months ago and am holding off to get a ton of labs next months so the results will tell me how the protocol is working. Purchase the book. There's more to the protocol than just supplements. :-)

heartlifetalk.com/forums GENERAL TOPICS » Strategies: Prevention, Mitigation of CVD » Plaque Stability & Plaque Regression - by slimjohn

slimjohn
The combination of niacin plus simvastatin reduces TAV (total atheroma volume) and PAV (percent atheroma volume), decreases coronary plaque volume and attenuates the inflammatory response in patients with intermediate coronary artery stenosis. See full article: The Effects of Statin and Niacin on Plaque Stability, Plaque Regression, Inflammation and Oxidative Stress in Patients With Mild to Moderate Coronary Artery Stenosis

heartlifetalk.com/forums Slimjohn's Supplement and Products List (75% coronary artery regression, 2007-2016)

heartlifetalk.com/forums - ADVANCED TOPICS » Cell & Mitochondria Health New Energy Plus! by slimjohn

I take early morning and late evenings: by slimjohn

Early Morning -

  • 1 each - Life Extension Super K with Advanced K2 Complex
  • 1 each - Vitacost Vitamin K2 (MK-7) with Nattokinase

Late Evening -

  • 1 each - Life Extension Super K with Advanced K2 Complex
  • 1 each - Vitacost Vitamin K2 (MK-7) with Nattokinase

Vitacost Vitamin K Complex

  • Vitamin K2 (as menaquinone-7) 200 mcg
  • Vitamin K1 (phyloquinne) 200 mcg

Vitacost Vitamin K2 (MK-7) with Nattokinase

  • MK-7 (Vitamin K2 as Menaquinone-7) 100 mcg
  • Nattokinase (from Natto Extract) 320 FU (Fibrin Units)

I take both mornings and evenings (for a couple of years now) to ensure I have 24 hour coverage. Does it work? Who knows? I will get CAC scan soon so that may give some indication if arterial inflammation has slowed expanding surfaces for possible calcification. What I do know is that it is better to have sufficient Ks than insufficient Ks with reduced level carboxylation of matrix GLA which makes for an arterial wall primer for calcification.

I also ensure that I get plenty of magnesium (Natural Calm, 600mg- 900mg) that inhibits the calcification (phosphate binding) chemistry. It all depends on the level of D3 (which varies over the day & night). Vitamin A (retinol) does prevent excessive level of D3 (A is antagonist of D3; visa versa). Note: Vitamin K is needed to help the body make blood clots; people taking anti-coagulant and anti-platelet medication should consult their doctor before adding Vitamin K to their daily regimen.

slimjohn on resveratrol

Aheartlifetalk.com/forums - DVANCED TOPICS » Cell & Mitochondria Health New Energy Plus!

        Swanson Ultra Apigenin
        90 capsules 50mg
        Pure grapefruit-derived flavonoid
        

It seems that resveratrol increases the bioavailability of apigenin when both taken together, at least in this study.

One of the most interesting I have noticed in doing exercise is that I do not get as tired as I used to and now when I take a break the recovery is fast. BTY, I use push mower to mow the lawn as exercise. I have a huge lawn area to mow. I can control the interval intensity as I strive for endurance. I can go for hours and not feel drained as I had in the past. I can not attribute this to conditioning because for the last several months I have not had grass to mow and the weather limited any running-trotting down the road. I have monitored this for days to see if this could just be a transient thing and it appears to be consistent.

To what I attribute this new energy? I have been taking high dosages of Apigenin and Resveratrol for a few weeks as part of my protocol, based on research, to slow cancerous B-lymphocyte growth, etc. Note: I do not take quercetin because it greatly slows thyroid function and may interfere with COMT gene function. Apigenin inhibits CD38 on these cells and selectively slows cell growth and may promote apoptosis (cell death) of these cancerous cells without harming healthy cells. At least, this is the best hypothesis of apigenin effect on CD38.

The only indication that apigenin and resveratrol are at play is the very noticeable increased energy. The increase in energy lead me to investigate possible causes. What I present here is my best possible explanation. I will continue to monitor.

Alternate ways of increasing NAD+ include 2 days/week fasting and calorie restriction which increase AMPK which then increases levels of NAD+. I have been doing both so complementary to apigenin and resveratrol supplementation.

I take apigenin (150mg/day) to inhibit CD38. I do not take NR – but do take niacin (1.5g/day) and resveratrol (supports NAD+). I am confident that the apigenin is freeing up additional NAD that is giving me a nice consistent level of energy (dare I say youthful energy?). Inhibiting CD38 is good for restoring mitochondria function. This should ameliorate some characteristics of atherosclerosis (e.g., endothelial dysfunction) over time.

My energy level remains high. This is not the energy sometimes associated with hyperactivity but more of an energy capability that maintains a good level with endurance reserve in which tiredness is only momentary. There is an element of feeling good enough to “get up off my butt and do something.” I’ve been physically active recently and even after 8-9 hours I still have energy in the tank. I will continue to monitor.

Now, what I do not know is whether this is a direct result of HIGH dosage EGCG and Curcumin along with apigenin (part of CLL protocol) or not. I am taking these supplements with BioPerine to increase bioavailability. I’ve taken these supplements before but not at these dosages. This new energy capacity may be due to increased level in blood stream due to increased bioavailability for each supplement. Or, it may simply be due to CR (calorie restriction) which does increase NAD+.

lconnolly - CYP3A4 is the “grapefruit effect” metabolizer. Hmmmm, your statin may lower your cholesterol too much if you take grapefruit juice beforehand. But CYP3A4 also metabolizes viagra…..would you want your viagra to last longer?? Take grapefruit juice before taking viagra. And I am not responsible for anything that happens.

lconnolly - Now Swanson’s apigenin is made from grapefruit…but it is a potent inhibitor of 2C9 not 3A4. Naringin, in the other hand is 3A4. 2C9 also metabolizes most of your nsaids. Would you like them to stick around longer?

Aheartlifetalk.com/forums - DVANCED TOPICS » Cell & Mitochondria Health Some Details here

heartlifetalk.com/forums/ slimjohn - Off to a new adventure + Updates

My current anti-CLL protocol:

        EGCG: 2g
        Curcumin: 1.8g (time-release)
        Apigenin: 150mg
        Resveratrol: 1g
        
        other supplements for atherosclerosis
        high dose fish oil
        high dose vitamin k2, mk-4 and mk-7
        

These are minimum effectiveness levels for EGCG and Curcumin based on Mayo Clinic and M.D. Anderson Cancer Center studies. The results, if any, are dose dependent. I may have to increase EGCG and Curcumin to 4g each; this means monitoring renal and liver function since these dosages are pretty rough on the body. Apigenin level is based on extrapolation and should be good enough to inhibit CD38. My thinking about apigenin is that if it inhibits CD38 to any degree, it will make the cancer cells more vulnerable to EGCG/Curcumin induction of apoptosis since cancer cells’ mitochondria are fragile anyway and this may help tilt the scale and aid the process.

Of course, I am taking other supplements for atherosclerosis and they are complementary in fighting cancer. For example, high dose fish oil (inhibits NF-kB) and high dose vitamin k2, mk-4 and mk-7 (depolarizes leukemia cell mitochondria membrane, i.e., shuts down energy production). Vitamins C, E, NAC, and other substances (e.g., SOD) that boost cell endogenous antioxidants (glutathione, catalase, SOD) are excluded because they support cancer cell function and proliferation.

heartlifetalk.com/forums - ADVANCED TOPICS » Cell & Mitochondria Health New Energy Plus!

Off to a new adventure + Updates

I have settled into a routine of heavy dose Curcumin and EGCG, each on alternate days (there oppose each other). I also added Resveratrol and Apigenin every day. All effect multiple pathways. Finally, I increased K2 Mk-4 to 60mg and will likely increase to 90mg since Mk-4 stops cancerous stem cells, etc. All based on research, human clinical trials, etc. Hopefully this will increase the time to treatment and allow time for newer non-chemo drugs to be introduced with better outcomes.

Recently, I have noticed an increase in energy level. I can mow (push type, for exercise) the lawn for hours and not feel exhausted as I had in the past. Energy comes from mitochondria so something is happening to provide more energy. It could be more new mitochondria (probably) or some mechanism that frees up ATP production (most likely).

heartlifetalk.com/forums/ I take early morning and late evenings:

I take early morning and late evenings:

        Early Morning -
        1 each - Life Extension Super K with Advanced K2 Complex
        1 each - Vitacost Vitamin K2 (MK-7) with Nattokinase
        
        Late Evening -
        1 each - Vitacost Ultra Vitamin K with Advanced K2 Complex
        1 each - Vitacost Vitamin K2 (MK-7) with Nattokinase
        
        Life Extension Super K with Advanced K2 Complex
           Vitamin C (as Ascorbyl palmitate) 10 mg
           Vitamin K1 (as phytonadione) 1000 mcg
           Vitamin K2 (as menaquinone-4) 1000 mcg
           Vitamin K2 (as menaquinone-7) 200 mcg
        
        Vitacost Vitamin K Complex
           Vitamin K2 (as menaquinone-7) 200 mcg 
           Vitamin K1 (phyloquinne) 200 mcg
        
        Vitacost Vitamin K2 (MK-7) with Nattokinase
           MK-7 (Vitamin K2 as Menaquinone-7) 100 mcg
           Nattokinase (from Natto Extract) 320  FU (Fibrin Units)
        

I take both mornings and evenings (for a couple of years now) to ensure I have 24 hour coverage. Does it work? Who knows? I will get CAC scan soon so that may give some indication if arterial inflammation has slowed expanding surfaces for possible calcification. What I do know is that it is better to have sufficient Ks than insufficient Ks with reduced level carboxylation of matrix GLA which makes for an arterial wall primer for calcification.

I also ensure that I get plenty of magnesium (Natural Calm, 600mg- 900mg) that inhibits the calcification (phosphate binding) chemistry. It all depends on the level of D3 (which varies over the day & night). Vitamin A (retinol) does prevent excessive level of D3 (A is antagonist of D3; visa versa). Note: Vitamin K is needed to help the body make blood clots; people taking anti-coagulant and anti-platelet medication should consult their doctor before adding Vitamin K to their daily regimen.

Web Trail