Genetic Testing

Post tags: | genetic_testing |
        Health + Ancestry Personal Genetic Service - Craig
        Order number: M1256498363453178
        Date ordered: October 12, 2017
        Kits ordered: 1
        Total: $208.95 
 Good News About Health Reports - April 6, 2017 By 23andMe under announcements

For this authorization, 23andMe conducted extensive validation studies for accuracy and user comprehension that met FDA standards.23andMe is now the only company authorized by the FDA to provide personal genetic health risk reports without a prescription. These reports provide individuals with information about genetic variants that could increase their personal risk for certain diseases. Learn More About 23andMe’s New Genetic Health Risk Reports - May 19, 2017 By 23andMe SNPwatch: Largest Alzheimer’s Genetic Studies To Date Identify Three New Susceptibility Genes

September 8, 2009 By ErinC under SNPWatch

cureality - Heart Health Forum >> 23andMe - thread 23andMe Is Terrifying, but Not for the Reasons the FDA Thinks

The genetic-testing company’s real goal is to hoard your personal data

com/magazine/201206/liz-welch/ The Way I Work: Anne Wojcicki, 23andMe

I understand that the information provided in my Promethease report is based on and that my report is for educational and research purposes only.

I understand that my report is deleted after 45 days but that I can download it before it is deleted and that I can regenerate it, if I create an account. uses Illumina OmniExpress Plus, reporting all SNP’s on that chip for $99. Current users will receive data for about ~47,000 of the SNPs in SNPedia. ~25,000 of these are in ClinVar.

23andMe $99 “ancestry only” product, is sufficient for Promethease, or the $199 “ancestry + health” product, which also includes carrier status reports. One time payment, lifetime membership. Both products use the (same) customized Illumina chip which covers 27038 of the 107204 SNPs in SNPedia. Less than 2,000 of these are known to be in ClinVar; presumably some of the proprietarily named “i-SNPs” correspond to ClinVar/SNPedia entries as well but 23andMe does not reveal which publicly or to its non-corporate users.

FamilyTreeDNA Family Finder uses an Illumina OmniExpress for autosomal ancestry testing for $79, including partial raw data download. It covers 13,732 of the SNPs in SNPedia, with ~2,000 of those being known to ClinVar.

  • The STR-based Y DNA tests such as the Y37, Y67 and Y111 tests, cannot be used with Promethease as they produce no SNP data.
  • The "Big Y" Y DNA test produces SNP data (more than 10,000,000 base pairs) that is accepted by Promethease (only the VCF format results, not the much larger BAM file). The "Big Y" test is only available to those who have already done STR-based Y DNA testing with FamilyTreeDNA.
  • Mitochondrial DNA test results (FASTA format) are not accepted by Promethease.
    • Alzheimer's disease

      Methylation Analysis

      This website looks at your methylation genetics just by reading your 23andMe raw data. After you receive your results from 23andMe, click on the Methylation Analysis link, follow the simple instructions, and you’ll see some of your methylation-related genetic polymorphisms. Studies have shown that DNA Methylation can be altered with vitamins such as B12, Folate, SAMe, and other methyl donors.

      Detox Profile

      The detox profile looks at gene SNPs of the Cytochrome P450 detox enzymes, amongst others. Certain genetic polymorphisms have been shown to impair detoxification of drugs, hormones, environmental toxins, xenobiotics, and more. Simply click on the Detox Profile link, follow the simple instructions provided on the website, and you’ll see a a list of relevant genetic polymorphisms. You Are Not the Result of Your Genes

      1209-dnaThe first thing to realize when you are using genetic data is that you are not the result of your genes (most of the time anyway). You are the result of your gene expression and heritable changes in your gene expression. This is also known as epigenetics. What does this mean? You can’t look at a piece of paper (or a website) and determine exactly what treatments or supplements you need based on your genetics. You also have to keep in mind, that there are a lot of SNPs that we don’t know much about. In fact, there are approximately 23.7 million SNPs identified. Out of these SNPs, only 14.5 million have been validated. The remaining 9.2 million SNPs are candidate SNPs. I guess you can say that in terms of genetics, genomics, and SNPs, we still don’t know a whole lot. We’re understanding what all of this means a little more each and every day, but it will take many years until we really know what most of these SNPs truly mean in terms of human health. A genetic methylation and detox panel only show you a very small number of SNPs that have been more or less well studied. We’re limited by what we know. And we are limited by what we don’t know. These small sets of SNPs may help give a picture of where to start with things like nutritional support of the methylation cycle, but these genes do not not define you. Through testing we can see all these genes, but we can’t see individual expression of these genes. Your environment and life experiences can change the expression of your genes at any moment in your life. For an example, the expression of the MAO-A gene on the methylation panel can change from serious trauma or violence.